Identification of selective N-pyridinsulfonyl indole based thiosemicarbazone derivatives as potential antiproliferative agents against lung cancer cells
Yazarlar (11)
Zahra Batool
Bahauddin Zakariya University, Pakistan
Bahauddin Zakariya University, Pakistan
Doç. Dr. Halil Şenol Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Rushba Saman Masood
Quaid-İ-Azam University, Pakistan
Quaid-İ-Azam University, Pakistan
Tugce Salduz
Üsküdar Üniversitesi, Türkiye
Üsküdar Üniversitesi, Türkiye
Arş. Gör. Fatma Betül Yoladı Atatürk Üniversitesi, Türkiye
Prof. Dr. Fahri Akbaş Bezmiâlem Vakıf Üniversitesi, Türkiye
Doç. Dr. Feyzi Sinan TOKALI Kafkas Üniversitesi, Türkiye
Norah A. Albekairi
College of Pharmacy, Suudi Arabistan
College of Pharmacy, Suudi Arabistan
Asıf Rasool
Nanjing University, Çin
Nanjing University, Çin
Zahıd Shafıq
Bahauddin Zakariya University, Pakistan
Bahauddin Zakariya University, Pakistan
Abdulrahman Alshammarı
College of Pharmacy, Suudi Arabistan
College of Pharmacy, Suudi Arabistan
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Rsc Advances (Q2) | ||
| Dergi ISSN | 2046-2069 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2026 |
| Cilt / Sayı / Sayfa | 16 / 34 / 33196–33212 | DOI | 10.1039/d6ra02731h |
| Makale Linki | https://doi.org/10.1039/d6ra02731h | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| Lung cancer remains one of the leading causes of cancer-related mortality worldwide and necessitates the development of novel targeted agents. In this study, a series of new thiosemicarbazone derivatives (5a–r) were synthesized and evaluated for their anticancer potential through combined in vitro and in silico approaches. Cytotoxic activities were assessed against lung adenocarcinoma cells (A549) and normal bronchial epithelial cells (BEAS-2B). Among the tested compounds, 5p emerged as the most potent derivative, exhibiting an IC50 value of 3.41 µM against A549 cells, superior to sorafenib (IC50 = 4.02). Importantly, 5p demonstrated a remarkably high selectivity index (SI = 17.5), substantially exceeding that of sorafenib (SI = 5.5), indicating preferential cytotoxicity toward cancer cells. Apoptosis assays revealed that 5p significantly induced apoptotic cell death in A549 cells, supporting that its … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |