Novel Quinazolinone Derivatives: Synthetic Analogues for the Treatment of Glaucoma, Alzheimers Disease and Diabetes Mellitus
Yazarlar (6)
Doç. Dr. Feyzi Sinan TOKALI Kafkas Üniversitesi, Türkiye
Doç. Dr. Parham Taslımı Bartın Üniversitesi, Türkiye
Prof. Dr. Burak Tüzün Sivas Cumhuriyet Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ahmet Karakuş Bartın Üniversitesi, Türkiye
Dr. Öğr. Üyesi Nastaran Sadeghıan Bartın Üniversitesi, Türkiye
Prof. Dr. İlhami Gülçin Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Chemistry and Biodiversity (Q3) | ||
| Dergi ISSN | 1612-1872 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2023 |
| Cilt / Sayı / Sayfa | 20 / 10 / – | DOI | 10.1002/cbdv.202301134 |
| Makale Linki | http://dx.doi.org/10.1002/cbdv.202301134 | ||
| UAK Araştırma Alanları |
Organik Kimya
Spektroskopi
Biyokimya
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| Özet |
| Quinazolinones, which represent an important part of nitrogen‐containing six‐membered heterocyclic compounds, are frequently used in drug design due to their wide biological activity properties. Therefore, the novel quinazolinones were synthesized from the reaction of acylated derivatives of 4‐hydroxy benzaldehyde with 3‐amino‐2‐alkylquinazolin‐4(3H)‐ones with good yields (85–94 %) and their structures were characterized using Fourier‐transform Infrared (FT‐IR), Nuclear Magnetic Resonance (1H‐NMR, 13C‐NMR), and High‐Resolution Mass Spectroscopy (HR‐MS). As the application of the synthesized compounds, their inhibition properties of the synthesized compounds on α‐Glucosidase (α‐Glu), Acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), and Carbonic anhydrase I–II (hCA I–II) metabolic enzymes were investigated. All compounds showed inhibition at nanomolar level with the Ki … |
| Anahtar Kelimeler |
| ADME/T | cholinesterases | diabetes | molecular docking | quinazolin-4(3H)-one |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 41 |
| Scopus | 41 |
| Google Scholar | 55 |