Synthesis and characterization of novel acyl hydrazones derived from vanillin as potential aldose reductase inhibitors
Yazarlar (8)
Prof. Dr. Yeliz Demir Ardahan Üniversitesi, Türkiye
Doç. Dr. Feyzi Sinan TOKALI Kafkas Üniversitesi, Türkiye
Doç. Dr. Erbay KALAY Kafkas Üniversitesi, Türkiye
Prof. Dr. Cüneyt Türkeş Erzincan Binali Yıldırım Üniversitesi, Türkiye
Pelin Tokalı
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Dr. Öğr. Üyesi Osman Nuri Aslan Atatürk Üniversitesi, Türkiye
Kıvılcım Şendil
Kafkas Üniversitesi, Türkiye
Kafkas Üniversitesi, Türkiye
Prof. Dr. Şükrü Beydemir Anadolu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Molecular Diversity (Q2) | ||
| Dergi ISSN | 1381-1991 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2023 |
| Cilt / Sayı / Sayfa | 27 / 4 / 1713–1733 | DOI | 10.1007/s11030-022-10526-1 |
| Makale Linki | http://dx.doi.org/10.1007/s11030-022-10526-1 | ||
| UAK Araştırma Alanları |
Organik Kimya
Spektroskopi
Biyokimya
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| Özet |
| In the polyol pathway, aldose reductase (AR) catalyzes the formation of sorbitol from glucose. In order to detoxify some dangerous aldehydes, AR is essential. However, due to the effects of the active polyol pathway, AR overexpression in the hyperglycemic state leads to microvascular and macrovascular diabetic problems. As a result, AR inhibition has been recognized as a potential treatment for issues linked to diabetes and has been studied by numerous researchers worldwide. In the present study, a series of acyl hydrazones were obtained from the reaction of vanillin derivatized with acyl groups and phenolic Mannich bases with hydrazides containing pharmacological groups such as morpholine, piperazine, and tetrahydroisoquinoline. The resulting 21 novel acyl hydrazone compounds were investigated as an inhibitor of the AR enzyme. All the novel acyl hydrazones derived from vanillin demonstrated activity … |
| Anahtar Kelimeler |
| Acyl hydrazones | ADME-Tox | Aldose reductase | Epalrestat | In silico study | Molecular docking | Vanillin |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 92 |
| Scopus | 86 |
| Google Scholar | 94 |