Genotoxicity in primary human peripheral lymphocytes after exposure to lithium titanate nanoparticles in vitro
Yazarlar (5)
Doç. Dr. Giray Buğra AKBABA Kafkas Üniversitesi, Türkiye
Hasan Türkez Erzurum Teknik Üniversitesi, Türkiye
Prof. Dr. Erdal Sönmez Atatürk Üniversitesi, Türkiye
Abdulgani Tatar Atatürk Üniversitesi, Türkiye
Prof. Dr. Mehmet Yılmaz Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | TOXICOLOGY AND INDUSTRIAL HEALTH (Q3) | ||
| Dergi ISSN | 0748-2337 Dergi Bilgileri (2016) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2016 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 31-12-2014 |
| Cilt / Sayı / Sayfa | 32 / 8 / 1423–1429 | DOI | 10.1177/0748233714562624 |
| Makale Linki | https://www.ncbi.nlm.nih.gov/pubmed/25552539 | ||
| UAK Araştırma Alanları |
Hücre Biyolojisi
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| Özet |
| Lithium titanate (LiTiO) nanoparticles (LTT NPs; <100 nm) are widely used in battery technology, porcelain enamels, and ceramic insulating bodies. With the increased applications of LTT NPs, the concerns about their potential human toxicity effects and their environmental impact were also increased. However, toxicity data for LTT NPs relating to human health are very limited. Therefore, the purpose of this study was to evaluate whether LTT NPs are able to induce genetic damage in human peripheral lymphocytes in vitro when taking into consideration that DNA damage plays an important role in carcinogenesis. With this aim, the chromosome aberrations (CA), sister chromatid exchanges (SCE), and micronucleus (MN) assays were used as genotoxicity end points. Human peripheral lymphocytes obtained from five healthy male volunteers were exposed to LTT NPs at final dispersed concentrations ranging from 0 to 1000 μg/mL for 72 h at 37°C. The obtained results indicated that LTT NPs compound did not induce DNA damage in human peripheral lymphocytes as depicted by CA/cell, SCE/cell, and MN/1000 cell values in all concentrations tested. In summary, our results revealed that exposure to LTT NPs is not capable of inducing DNA lesions in human peripheral lymphocytes for the first time. |
| Anahtar Kelimeler |
| Lithium titanate | DNA damage | human lymphocytes | nanoparticle | in vitro |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 7 |