Neuroprotective Effect of Chitosan Nanoparticle–Delivered Orientin Against Hypoxia-Induced Brain Injury in Rats
Yazarlar (9)
İhsan Topaloğlu Kafkas Üniversitesi, Türkiye
Çağrı Atasoy Kafkas Üniversitesi, Türkiye
Gülfem Özduygu
University of Health Sciences, Türkiye
University of Health Sciences, Türkiye
Eren Erdoğdu
İstanbul Tıp Fakültesi, Türkiye
İstanbul Tıp Fakültesi, Türkiye
Doç. Dr. Guntug Batihan Kafkas Üniversitesi, Türkiye
Volkan Gelen Kafkas Üniversitesi, Türkiye
Doç. Dr. Ali YEŞİLDAĞ Kafkas Üniversitesi, Türkiye
Prof. Dr. Adem Kara Erzurum Technical University, Türkiye
Doç. Dr. Elif Erbaş Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Molecular Neurobiology (Q1) | ||
| Dergi ISSN | 0893-7648 Dergi Bilgileri (2026) | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2026 |
| Cilt / Sayı / Sayfa | 63 / 1 / – | DOI | 10.1007/s12035-026-06076-4 |
| Makale Linki | https://link.springer.com/article/10.1007/s12035-026-06076-4 | ||
| UAK Araştırma Alanları |
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| Özet |
| Reduced brain oxygenation rapidly amplifies oxidative and inflammatory injury, creating a self-perpetuating cascade that can end in neuronal loss. Orientin can activate Nrf2/ARE-dependent antioxidant responses and suppress NF-κB–mediated inflammation, but poor solubility and limited bioavailability weaken its therapeutic impact. Here, we used chitosan nanoparticles (CNPs) to improve Orientin delivery and evaluated the protective effects of CNPs/Orientin on oxidative stress, inflammation, and apoptosis in hypoxia-induced brain injury. Forty-eight male Wistar albino rats were split into eight groups: (Control, Orientin, CNPs, CNPs/Orientin, Hypoxia, Hypoxia+Orientin, Hypoxia+CNPs, Hypoxia+CNPs/Orientin). The hypoxia model was applied with an 8% O₂+92% N₂ gas mixture for 8 h per day for 7 days. Orientin (40 mg/kg/day, i.p.) was administered simultaneously with the hypoxia period. MDA, SOD, GSH … |
| Anahtar Kelimeler |
| Chitosan nanoparticle | Hypoxia | Inflammation | Neuroprotection | Orientin | Oxidative stress |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 2 |
| Google Scholar | 2 |