Studies on the interaction between zinc hydroxybenzoite complex and genomic DNA
Yazarlar (4)
Ali Arslantas Kafkas Üniversitesi, Türkiye
A. Kadir Devrim
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Neceti Kaya
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Prof. Dr. Hacali NECEFOĞLU Kafkas Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | International Journal of Molecular Sciences | ||
| Dergi ISSN | 1422-0067 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2006 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 07-04-2006 |
| Cilt / Sayı / Sayfa | 7 / 4 / 111–118 | DOI | 10.3390/i7040111 |
| Makale Linki | https://www.mdpi.com/1422-0067/7/4/111/pdf?version=1403128996 | ||
| UAK Araştırma Alanları |
Anorganik Kimya
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| Özet |
| Zinc-Hydroxybenzoite ([Zn (H20)6] (p-HO-C6H4COO)22H20) complex which was synthesized and characterized by instrumental methods and the DNA samples which had been isolated from cattle were allowed to interact at 37 ºC for different time periods. The interaction of genomic DNA with this complex has been followed by agarose gel electrophoresis at 50 V for 2 h. When DNA samples were allowed to interact with this metal complex, it was found that band intensities changed with the concentrations of the complex. In the result of interaction between this complex and genomic DNA samples, it was determined that the intensities of bands were changed at the different concentrations of the complex. The brightness of the bands was increased and mobility of the bands was decreased, indicating the occurrence of increased covalent binding of the metal complex with DNA. In this study it was concluded that the damage effect of ascorbate was reduced by Zinc-Hydroxybenzoite. |
| Anahtar Kelimeler |
| Ascorbate | DNA damage | Gel electrophoresis | Genomic DNA | Zinc-hydroxybenzoite |
| Atıf Sayıları | |
| Web of Science | 12 |
| Scopus | 12 |
| Google Scholar | 16 |