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Interactoon of genomic DNA with manganase II p aminobenzoate complex   
Yazarlar
Ali Arslantas
Kafkas Üniversitesi, Turkey
A. Kadir Devrim
Mehmet Akif University, Turkey
Mahmut Sözmen
Kafkas Üniversitesi, Veteriner Fakültesi, Turkey
Prof. Dr. Hacali NECEFOĞLU Prof. Dr. Hacali NECEFOĞLU
Kafkas Üniversitesi, Türkiye
Özet
The complex of bis-(p-aminobnzoato)tetraquamanganese(II) was synthesized according to the literature method. The interaction between bis-(p-aminobnzoato)tetraquamanganese(II) and cat genomic DNA was studied by gel electrophoresis, fluorescence spectroscopy, UV-visible and viscosity methods. The results suggest that the complex binds with DNA by intercalating through the ligand. The intrinsic binding constant Kb of [Mn(p-H2N-C6H4COO)2].4H2O (MnPAB) was determined as 2.9 x 105 M-1. The binding constant shows that the complex binds to DNA. Also all the other experimental results proved that [Mn(p-H2N-C6H4COO)2].4H2O could attach to DNA mainly by intercalative binding mode.
Anahtar Kelimeler
DNA binding | Gel electrophorsis | Interaction | Manganese(II) | P-aminobenzoic acid
Makale Türü Özgün Makale
Makale Alt Türü SCOPUS dergilerinde yayımlanan tam makale
Dergi Adı RASAYAN JOURNAL F CHEMISTRY
Dergi ISSN 0974-1496
Dergi Tarandığı Indeksler Scopus
Makale Dili İngilizce
Basım Tarihi 01-2010
Cilt No 3
Sayı 2
Sayfalar 201 / 206
Atıf Sayıları
SCOPUS 2

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