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Studies on Oxidative Cleavage Activity and DNA Binding of Zinc Complexes with Diaquabis N N diethylenenicotinamide bis salicylato and Diaquabis N N diethylnicotinamide bis 4 nitrobenzoato      
Yazarlar
A. Arslantas
Kafkas Üniversitesi, Turkey
Prof. Dr. Hacali NECEFOĞLU Prof. Dr. Hacali NECEFOĞLU
Kafkas Üniversitesi, Türkiye
M. Sozmen
Kafkas Üniversitesi, Turkey
Özet
The oxidative cleavage and binding of cat DNA with the Zn(II) complexes of diaquabis(N,N-diethylenenicotinamide)bis(salicylato) and diaquabis(N,N-diethylnicotinamide)bis(4-nitrobenzoato), in an aqueous solutions at pH 7.0, have been investigated as a function of the metal complex-DNA by UV absorption spectrophotometry, viscosity and electrophoresis measurments. In this study, the interactions were compared between DNA and the two zinc(II) complexes. The gel electrophoresis study showed that both of the complexes cleaved the cat DNA under physiological conditions in the presence of H2O2. Absorption spectroscopy and viscosity measurement indicate that the complexes bind to DNA by intercalative binding modes. The results confirm for an intercalative interaction of both complex 1 and 2 with DNA, showing complex 1 has more affinity than complex 2.
Anahtar Kelimeler
Zinc(II) | DNA | Oxidative cleavage | Electrophoresis | DNA-binding
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı ASIAN JOURNAL OF CHEMISTRY
Dergi ISSN 0970-7077
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 11-2010
Cilt No 22
Sayı 10
Sayfalar 7648 / 7654
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları

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